Inference of single-cell phylogenies from lineage tracing data using Cassiopeia
Abstract
The pairing of CRISPR/Cas9-based gene editing with massively parallel single-cell readouts now enables large-scale lineage tracing. However, the rapid growth in complexity of data from these assays has outpaced our ability to accurately infer phylogenetic relationships. First, we introduce Cassiopeia—a suite of scalable maximum parsimony approaches for tree reconstruction. Second, we provide a simulation framework for evaluating algorithms and...
Paper Details
Title
Inference of single-cell phylogenies from lineage tracing data using Cassiopeia
Published Date
Apr 14, 2020
Journal
Volume
21
Issue
1
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