The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression

Volume: 23, Issue: 4, Pages: 101030 - 101030
Published: Apr 1, 2020
Abstract
•Setd5+/– mice manifest syndromic autism-related phenotypes•SETD5 recruits the HDAC3 complex to the rDNA promoter•SETD5 deficiency reduces rRNA abundance and attenuates translational activity•SETD5 deficiency inhibits cyclin D1 mRNA translation and neural cell proliferation Haploinsufficiency of SETD5 is implicated in syndromic autism spectrum disorder (ASD), but the molecular mechanism underlying the pathological role of this protein has...
Paper Details
Title
The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression
Published Date
Apr 1, 2020
Journal
Volume
23
Issue
4
Pages
101030 - 101030
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