HIV-1 Broadly Neutralizing Antibodies Take the Road Less Traveled, and That Makes All the Difference

Broadly neutralizing antibodies (bnAbs) against HIV-1 provide critical insights into co-evolution between the virus and human B cell responses. In this issue of Cell Host & Microbe, Shen et al., 2020Shen C.-H. DeKosky B.J. Guo Y. Xu K. Gu Y. Kilam D. Ko S.H. Kong R. Liu K. Louder M.K. VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.Cell Host Microbe. 2020; 27 (this...