Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage

Volume: 88, Issue: 1, Pages: 56 - 66
Published: May 7, 2020
Abstract
Observational studies point to an inverse correlation between low-density lipoprotein (LDL) cholesterol levels and risk of intracerebral hemorrhage (ICH), but it remains unclear whether this association is causal. We tested the hypothesis that genetically elevated LDL is associated with reduced risk of ICH.We constructed one polygenic risk score (PRS) per lipid trait (total cholesterol, LDL, high-density lipoprotein [HDL], and triglycerides)...
Paper Details
Title
Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage
Published Date
May 7, 2020
Volume
88
Issue
1
Pages
56 - 66
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