Sample preparation for structural and functional analyses of the STRA6 receptor for retinol-binding protein

Published: Jan 1, 2020
Abstract
STRA6 (stimulated by retinoic acid 6) is a 75kDa polytopic transmembrane protein that facilitates cellular retinol uptake from retinol-binding protein (RBP). Structural characterization of STRA6 from Danio rerio purified in detergent and reconstituted in amphipol A8-35 was achieved by single-particle cryo-electron microscopy (cryo-EM). This provided the first high-resolution snapshot of this protein, showing a novel topology of a tightly...
Paper Details
Title
Sample preparation for structural and functional analyses of the STRA6 receptor for retinol-binding protein
Published Date
Jan 1, 2020
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