Fat mass and fat‐free mass in relation to cardiometabolic diseases: a two‐sample Mendelian randomization study

High body mass index is causally associated with most cardiovascular diseases but not stroke [1]. Body mass index is determined by the content of both fat mass and fat-free mass, which may have opposite effects on cardiometabolic diseases. A Mendelian randomization (MR) study that utilized 82 single-nucleotide polymorphisms (SNPs) associated with fat mass or fat-free mass index revealed that fat mass index but not fat-free mass index was...