Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
Abstract
The hexosamine biosynthetic pathway (HBP) plays critical roles in nutrient sensing, stress response, and cell growth. However, its contribution to cardiac hypertrophic growth and heart failure remains incompletely understood. Here, we show that the HBP is induced in cardiomyocytes during hypertrophic growth. Overexpression of Gfat1 (glutamine:fructose-6-phosphate amidotransferase 1), the rate-limiting enzyme of HBP, promotes cardiomyocyte...
Paper Details
Title
Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling
Published Date
Apr 14, 2020
Journal
Volume
11
Issue
1
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