A type VI secretion system delivers a cell wall amidase to target bacterial competitors

Volume: 114, Issue: 2, Pages: 308 - 321
Published: Apr 22, 2020
Abstract
The human pathogen Pseudomonas aeruginosa harbors three paralogous zinc proteases annotated as AmpD, AmpDh2, and AmpDh3, which turn over the cell wall and cell wall-derived muropeptides. AmpD is cytoplasmic and plays a role in the recycling of cell wall muropeptides, with a link to antibiotic resistance. AmpDh2 is a periplasmic soluble enzyme with the former anchored to the inner leaflet of the outer membrane. We document, herein, that the type...
Paper Details
Title
A type VI secretion system delivers a cell wall amidase to target bacterial competitors
Published Date
Apr 22, 2020
Volume
114
Issue
2
Pages
308 - 321
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