Formulation and characterisation of insulin-loaded chitosan nanoparticles capable of inducing glucose uptake in skeletal muscle cells in vitro

A successful oral protein nanocarrier needs to exhibit the following characteristics: stability in the gastrointestinal (GI) tract, drug release at specific site, overcoming high mucus turnover, mucoadhesive properties and enhanced epithelial absorption. The purpose of this research was to examine the potential of complex coacervation technique for manufacturing of insulin-loaded chitosan-Dz13Scr nanoparticles. The nanoparticles were...