Convergent Evolution, Evolving Evolvability, and the Origins of Lethal Cancer
Abstract
Advances in curative treatment to remove the primary tumor have increased survival of localized cancers for most solid tumor types, yet cancers that have spread are typically incurable and account for >90% of cancer-related deaths. Metastatic disease remains incurable because, somehow, tumors evolve resistance to all known compounds, including therapies. In all of these incurable patients, de novo lethal cancer evolves capacities for both...
Paper Details
Title
Convergent Evolution, Evolving Evolvability, and the Origins of Lethal Cancer
Published Date
Jun 1, 2020
Journal
Volume
18
Issue
6
Pages
801 - 810
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Notes
History