Reduced neurosteroid potentiation of GABA _A receptors in epilepsy and depolarized hippocampal neurons

Objective Neurosteroids regulate neuronal excitability by potentiating γ ‐aminobutyric acid type‐A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is altered. We tested whether similar changes occur in patients with epilepsy and if depolarization‐induced increases in neuronal activity can replicate this effect. Methods We determined GABAR α 4...