Remodeling of the Core Leads HIV-1 Preintegration Complex into the Nucleus of Human Lymphocytes
Abstract
How the reverse-transcribed genome reaches the host nucleus remains a main open question related to the infectious cycle of HIV-1. The HIV-1 core has a size of ∼100 nm, largely exceeding that of the NPC channel (∼39 nm). Thus, a rearrangement of the viral CA protein organization is required to achieve an effective nuclear translocation. The mechanism of this process remains undefined due to the lack of a technology capable of visualizing...
Paper Details
Title
Remodeling of the Core Leads HIV-1 Preintegration Complex into the Nucleus of Human Lymphocytes
Published Date
May 18, 2020
Journal
Volume
94
Issue
11
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