Circulating uromodulin inhibits vascular calcification by interfering with pro-inflammatory cytokine signalling
Abstract
Uromodulin is produced exclusively in the kidney and secreted into both urine and blood. Serum levels of uromodulin are correlated with kidney function and reduced in chronic kidney disease (CKD) patients, but physiological functions of serum uromodulin are still elusive. This study investigated the role of uromodulin in medial vascular calcification, a key factor associated with cardiovascular events and mortality in CKD patients.Experiments...
Paper Details
Title
Circulating uromodulin inhibits vascular calcification by interfering with pro-inflammatory cytokine signalling
Published Date
Apr 3, 2020
Journal
Volume
117
Issue
3
Pages
930 - 941
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