A novel virtual barcode strategy for accurate panel-wide variant calling in circulating tumor DNA
Abstract
Background Hybrid capture-based next-generation sequencing of DNA has been widely applied in the detection of circulating tumor DNA (ctDNA). Various methods have been proposed for ctDNA detection, but low-allelic-fraction (AF) variants are still a great challenge. In addition, no panel-wide calling algorithm is available, which hiders the full usage of ctDNA based ‘liquid biopsy’. Thus, we developed the VBCALAVD (Virtual Barcode-based Calling...
Paper Details
Title
A novel virtual barcode strategy for accurate panel-wide variant calling in circulating tumor DNA
Published Date
Apr 3, 2020
Journal
Volume
21
Issue
1
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