Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation
Abstract
Systemic inflammation can lead to coagulopathy and disseminated intravascular coagulation (DIC). In prior studies, the recombinant A2 domain of human von Willebrand factor (VWF; A2 protein) attenuated DIC and decreased mortality in lipopolysaccharide (LPS)-treated mice. Here, we performed studies to dissect the mechanism by which the A2 protein moderates DIC. We used confocal microscopy to analyze the fibrin clot structure in plasma from healthy...
Paper Details
Title
Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation
Published Date
Apr 7, 2020
Journal
Volume
4
Issue
7
Pages
1340 - 1349
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