Human liver CD8+ MAIT cells exert TCR/MR1-independent innate-like cytotoxicity in response to IL-15

•MAIT cells activated by IL-15 exert TCR/MR1-independent, innate-like cytotoxicity. •Innate-like cytotoxicity of MAIT cells is dependent on NKG2D, granzyme B, and CD2. •PI3K–mTOR signaling is required for innate-like cytotoxicity of MAIT cells. •MAIT cells exhibit activated and cytotoxic phenotypes during acute hepatitis A. •MAIT cells may contribute to liver injury during acute hepatitis A. Background & Aims Mucosal-associated invariant T...