Original paper
Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30
Abstract
Mitochondrial form and function are closely interlinked in homeostasis and aging. Inhibiting mitochondrial translation is known to increase lifespan in C. elegans, and is accompanied by a fragmented mitochondrial network. However, whether this link between mitochondrial translation and morphology is causal in longevity remains uncharacterized. Here, we show in C. elegans that disrupting mitochondrial network homeostasis by blocking fission or...
Paper Details
Title
Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30
Published Date
Apr 7, 2020
Journal
Volume
219
Issue
6
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Notes
History