Adipose stem cells from patients with Crohn’s disease show a distinctive DNA methylation pattern
Abstract
Background Crohn’s disease (CD) is characterized by persistent inflammation and ulceration of the small or large bowel, and expansion of mesenteric adipose tissue, termed creeping fat (CF). We previously demonstrated that human adipose-derived stem cells (hASCs) from CF of patients with CD exhibit dysfunctional phenotypes, including a pro-inflammatory profile, high phagocytic capacity, and weak immunosuppressive properties. Importantly, these...
Paper Details
Title
Adipose stem cells from patients with Crohn’s disease show a distinctive DNA methylation pattern
Published Date
Apr 6, 2020
Journal
Volume
12
Issue
1
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