Precise Tuning of Cortical Contractility Regulates Cell Shape during Cytokinesis
Abstract
The mechanical properties of the actin cortex regulate shape changes during cell division, cell migration, and tissue morphogenesis. We show that modulation of myosin II (MII) filament composition allows tuning of surface tension at the cortex to maintain cell shape during cytokinesis. Our results reveal that MIIA generates cortex tension, while MIIB acts as a stabilizing motor and its inclusion in MII hetero-filaments reduces cortex tension....
Paper Details
Title
Precise Tuning of Cortical Contractility Regulates Cell Shape during Cytokinesis
Published Date
Apr 1, 2020
Journal
Volume
31
Issue
1
Pages
107477 - 107477
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