TGFβ1 orchestrates renal fibrosis following Escherichia coli pyelonephritis
Abstract
Renal scarring after pyelonephritis is linked to long-term health risks for hypertension and chronic kidney disease. Androgen exposure increases susceptibility to, and severity of, uropathogenic Escherichia coli (UPEC) pyelonephritis and resultant scarring in both male and female mice, while anti-androgen therapy is protective against severe urinary tract infection (UTI) in these models. This work employed androgenized female C57BL/6 mice to...
Paper Details
Title
TGFβ1 orchestrates renal fibrosis following Escherichia coli pyelonephritis
Published Date
Mar 1, 2020
Journal
Volume
8
Issue
6
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