The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis
Abstract
•HIF-1α is a protective factor against Leishmania donovani infection•In absence of HIF-1α, lipogenesis is induced via BNIP3/mTOR/SREBP-1c modulation•Blockage of lipogenesis reverts HIF-1α-associated Leishmania susceptibility•HIF1A polymorphism correlates with susceptibility to infection Hypoxia-inducible factor-1 alpha (HIF-1α) is considered a global regulator of cellular metabolism and innate immune cell functions. Intracellular pathogens such...
Paper Details
Title
The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis
Published Date
Mar 1, 2020
Journal
Volume
30
Issue
12
Pages
4052 - 4064.e7
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