Berberine Protects Against Simulated Ischemia/Reperfusion Injury-Induced H9C2 Cardiomyocytes Apoptosis In Vitro and Myocardial Ischemia/Reperfusion-Induced Apoptosis In Vivo by Regulating the Mitophagy-Mediated HIF-1α/BNIP3 Pathway

Berberine (BBR) has a variety of pharmacological activities and is widely used in Asian countries. This study aimed to investigate the protective mechanism of BBR against myocardial ischemia-reperfusion injury (MIRI) and establish a scientific basis for the clinical application of BBR. In vitro experiments, BBR pretreatment regulated autophagy-related protein expression, induced cell proliferation and autophagosome formation, and reduced the...