Faecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice

Objectives Emerging evidence suggests that the microbiome plays an important role in the pathogenesis of osteoarthritis (OA). We aimed to test the two-hit model of OA pathogenesis and potentiation in which one ‘hit’ is provided by an adverse gut microbiome that activates innate immunity; the other ‘hit’ is underlying joint damage. Methods Medical history, faecal and blood samples were collected from human healthy controls (OA-METS-, n=4), knee...