HPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53.

Volume: 27, Issue: 9, Pages: 2537 - 2551
Published: Mar 23, 2020
Abstract
E6 oncoprotein derived from high-risk human papillomavirus (HPV) drives the development of cervical cancer through p53 degradation. Because cervical cancer therapies to inactivate HPV or E6 protein are not available, alternative strategies are required. Here, we show that HPV-mediated nuclear export of human heterochromatin protein 1γ (HP1γ) reduces the stability of p53 through UBE2L3-mediated p53 polyubiquitination during cervical cancer...
Paper Details
Title
HPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53.
Published Date
Mar 23, 2020
Volume
27
Issue
9
Pages
2537 - 2551
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