Functional informed genome‐wide interaction analysis of body mass index, diabetes and colorectal cancer risk

Body mass index (BMI) and diabetes are established risk factors for colorectal cancer (CRC), likely through perturbations in metabolic traits (e.g. insulin resistance and glucose homeostasis). Identification of interactions between variation in genes and these metabolic risk factors may identify novel biologic insights into CRC etiology.To improve statistical power and interpretation for gene-environment interaction (G × E) testing, we tested...