Robust nonlinear parameter estimation in tracer kinetic analysis using infinity norm regularization and particle swarm optimization
Abstract
In positron emission tomography (PET) studies, the voxel-wise calculation of individual rate constants describing the tracer kinetics is quite challenging because of the nonlinear relationship between the rate constants and PET data and the high noise level in voxel data. Based on preliminary simulations using a standard two-tissue compartment model, we can hypothesize that it is possible to reduce errors in the rate constant estimates when...
Paper Details
Title
Robust nonlinear parameter estimation in tracer kinetic analysis using infinity norm regularization and particle swarm optimization
Published Date
Apr 1, 2020
Journal
Volume
72
Pages
60 - 72
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