Murine double minute-2 mediates exercise-induced angiogenesis in adipose tissue of diet-induced obese mice
Abstract
This study aimed to determine the effects of physical exercise on the angio-adaptive response in adipose tissue following weight loss in a mouse model of diet-induced obesity. We hypothesized that physical exercise stimulates angiogenesis through the regulation of Vascular endothelial growth factor-A (VEGF-A) pro-/Thrombospondin-1 (TSP-1) anti-angiogenic signal under the control of the Murine double-minute 2/Forkhead box Os (Mdm2/FoxOs) axis, as...
Paper Details
Title
Murine double minute-2 mediates exercise-induced angiogenesis in adipose tissue of diet-induced obese mice
Published Date
Jul 1, 2020
Journal
Volume
130
Pages
104003 - 104003
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