Controlling Smad4 signaling with a Wip

Members of the transforming growth factor‐β (TGF‐β) family play key roles in embryogenesis and in maintaining tissue homeostasis, and their perturbation can result in a broad range of diseases. One way TGF‐β family signaling pathways are kept in check is by reversible (de)phosphorylation of intracellular Smad effectors. In this issue of EMBO Reports , Park et al [1] identify the phosphatase wild‐type p53‐induced phosphatase 1 (Wip1) as a...