Clinicopathological and genomic correlates of programmed cell death ligand 1 (PD-L1) expression in nonsquamous non-small-cell lung cancer

•PD-L1 expression is highly variable in nonsquamous NSCLC and is associated with distinct clinicopathological and genomic features.•Tobacco exposure, stage at diagnosis, and tumor mutational burden are associated with PD-L1 expression.•PD-L1 expression ≥50% is associated with copy gain of CD274 (PD-L1), PDCD1LG2 (PD-L2), JAK2, and the 9p24.1 locus.•PD-L1 negativity is associated with STK11, EGFR, CTNNB1, APC, and SMARCA4 mutations, as well as...