Inhibition of ornithine decarboxylase restores hypoxic pulmonary vasoconstriction in endotoxemic mice
Abstract
Endotoxemia impairs hypoxic pulmonary vasoconstriction which leads to systemic hypoxemia. This derogation is attributable to increased activity of nitric oxide synthase 2 and arginase metabolism. Gene expression analysis has shown increased expression of ornithine decarboxylase in lungs of endotoxemic mice, a downstream enzyme of arginase metabolism. The aim of this study was to investigate whether inhibition of ornithine decarboxylase increases...
Paper Details
Title
Inhibition of ornithine decarboxylase restores hypoxic pulmonary vasoconstriction in endotoxemic mice
Published Date
Oct 1, 2020
Journal
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