Helicobacter pylori-induced adrenomedullin modulates IFN-γ-producing T-cell responses and contributes to gastritis

Adrenomedullin (ADM) is a multifunctional peptide that is expressed by many surface epithelial cells, but its relevance to Helicobacter pylori (H. pylori) -induced gastritis is unknown. Here, we found that gastric ADM expression was elevated in gastric mucosa of H. pylori -infected patients and mice. In H. pylori -infected human gastric mucosa, ADM expression was positively correlated with the degree of gastritis; accordingly, blockade of ADM...