Unwinding Fibrosis in Peyronie's Disease

Fibrosis is defined as the excess accumulation of extracellular matrix proteins in response to chronic injury or inflammation.1 Peyronie's disease (PD) is a fibrotic disorder affecting the penile tunica albuginea (TA), characterized by the formation of a plaque that may lead to pain, curvature, or erectile dysfunction.2 The first observation of PD dates back to 1561, when it was reported by Fallopius and Vesalius, but it was the French surgeon...