Reactive oxygen species triggers unconventional secretion of antioxidants and Acb1
Abstract
Nutrient deprivation triggers the release of signal-sequence–lacking Acb1 and the antioxidant superoxide dismutase 1 (SOD1). We now report that secreted SOD1 is functionally active and accompanied by export of other antioxidant enzymes such as thioredoxins (Trx1 and Trx2) and peroxiredoxin Ahp1 in a Grh1-dependent manner. Our data reveal that starvation leads to production of nontoxic levels of reactive oxygen species (ROS). Treatment of cells...
Paper Details
Title
Reactive oxygen species triggers unconventional secretion of antioxidants and Acb1
Published Date
Mar 19, 2020
Journal
Volume
219
Issue
4
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