Slco2a1 deficiency exacerbates experimental colitis via inflammasome activation in macrophages: a possible mechanism of chronic enteropathy associated with SLCO2A1 gene
Abstract
Loss-of-function mutations in the solute carrier organic anion transporter family, member 2a1 gene ( SLCO2A1 ), which encodes a prostaglandin (PG) transporter, have been identified as causes of chronic nonspecific multiple ulcers in the small intestine; however, the underlying mechanisms have not been revealed. We, therefore, evaluated the effects of systemic knockout of Slco2a1 ( Slco2a1 −/− ) and conditional knockout in intestinal epithelial...
Paper Details
Title
Slco2a1 deficiency exacerbates experimental colitis via inflammasome activation in macrophages: a possible mechanism of chronic enteropathy associated with SLCO2A1 gene
Published Date
Mar 17, 2020
Journal
Volume
10
Issue
1
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