Glucagon‐Like Peptide‐1: Actions and Influence on Pancreatic Hormone Function
Abstract
GLP-1 was described as an incretin over 30 years ago. GLP-1 is encoded by the preproglucagon gene (Gcg), which is expressed in the intestine, the pancreas, and the central nervous system. GLP-1 activates GLP-1 receptors (GLP-1r) on the β-cell to induce insulin secretion in a glucose-dependent manner. GLP-1 also inhibits α-cell secretion of glucagon. As few, if any, GLP-1r are expressed on α-cells, indirect regulation, via β- or δ-cell products...
Paper Details
Title
Glucagon‐Like Peptide‐1: Actions and Influence on Pancreatic Hormone Function
Published Date
Mar 12, 2020
Journal
Pages
577 - 595
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