Mutational landscape differences between young-onset and older-onset breast cancer patients

The incidence of breast cancer among young women (aged ≤40 years) has increased in North America and Europe. Fewer than 10% of cases among young women are attributable to inherited BRCA1 or BRCA2 mutations, suggesting an important role for somatic mutations. This study investigated genomic differences between young- and older-onset breast tumours.In this study we characterized the mutational landscape of 89 young-onset breast tumours (≤40 years)...