A unique DNA-binding mode of African swine fever virus AP endonuclease
Abstract
African swine fever virus (ASFV) is highly contagious and can cause lethal disease in pigs. ASFV is primarily replicated in the cytoplasm of pig macrophages, which is oxidative and caused constant damage to ASFV genome. ASFV AP endonuclease ( Asfv AP) catalyzes DNA cleavage reaction at the abasic site and is a key enzyme of ASFV base excision repair (BER) system. Although it plays an essential role in ASFV survival in host cells, the basis...
Paper Details
Title
A unique DNA-binding mode of African swine fever virus AP endonuclease
Published Date
Mar 17, 2020
Journal
Volume
6
Issue
1
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