Quantitative proteomic analysis of the association between decreasing O‑GlcNAcylation and metastasis in MCF‑7 breast cancer cells

Breast cancer is the most common type of cancer and leading cause of cancer‑associated mortality in women worldwide. O‑linked N‑acetyl glucosaminylation (O‑GlcNAcylation) is a dynamic post‑translational modification of nuclear, cytoplasmic and mitochondrial proteins. Mounting evidence suggests that abnormal O‑GlcNAcylation status is associated with cancer malignancy. In our previous study, it was reported that O‑GlcNAc and O‑GlcNAc transferase...