Mechanical Regulation of Neurite Polarization and Growth: A Computational Study
Abstract
The densely packed microtubule (MT) array found in neuronal cell projections (neurites) serves two fundamental functions simultaneously: it provides a mechanically stable track for molecular motor-based transport and produces forces that drive neurite growth. The local pattern of MT polarity along the neurite shaft has been found to differ between axons and dendrites. In axons, the neurons’ dominating long projections, roughly 90% of the MTs...
Paper Details
Title
Mechanical Regulation of Neurite Polarization and Growth: A Computational Study
Published Date
Apr 1, 2020
Journal
Volume
118
Issue
8
Pages
1914 - 1920
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