N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition
Abstract
N-Acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase primarily found in the endosomal–lysosomal compartment of innate and adaptive immune cells. NAAA catalyzes the hydrolytic deactivation of palmitoylethanolamide (PEA), a lipid-derived peroxisome proliferator-activated receptor-α (PPAR-α) agonist that exerts profound anti-inflammatory effects in animal models. Emerging evidence points to NAAA-regulated PEA signaling at...
Paper Details
Title
N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition
Published Date
Mar 19, 2020
Volume
63
Issue
14
Pages
7475 - 7490
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