Platelet and Monocyte Activity Markers and Mortality in Patients with End-Stage Renal Disease

BACKGROUND The association of platelet and monocyte activity markers with long-term mortality was assessed in hemodialysis (HD) patients. METHODS In 41 HD patients (25 male, 16 female), surface expression of CD40L and CD62P on platelets, tissue factor (TF) binding on monocytes, and platelet-monocyte aggregates were measured by flow cytometry. Plasma levels of MCP-1, IL-6, TNFα, and soluble CD40L were analyzed by enzyme linked immunosorbent...