Metabolic control analysis of hepatic glycogen synthesis in vivo
Volume: 117, Issue: 14, Pages: 8166 - 8176
Published: Mar 18, 2020
Abstract
Multiple insulin-regulated enzymes participate in hepatic glycogen synthesis, and the rate-controlling step responsible for insulin stimulation of glycogen synthesis is unknown. We demonstrate that glucokinase (GCK)-mediated glucose phosphorylation is the rate-controlling step in insulin-stimulated hepatic glycogen synthesis in vivo, by use of the somatostatin pancreatic clamp technique using [13C6]glucose with metabolic control analysis (MCA)...
Paper Details
Title
Metabolic control analysis of hepatic glycogen synthesis in vivo
Published Date
Mar 18, 2020
Volume
117
Issue
14
Pages
8166 - 8176
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