SUN-456 MONOGENIC NEPHROTIC SYNDROME IN NIGERIAN CHILDREN

The genetic architecture of idiopathic nephrotic syndrome (NS) in African children is unknown despite evidence pointing to racial differences in the prevalence and clinical course of NS. The objective was to determine the frequency of single gene mutations in Nigerian children with idiopathic NS. Genomic DNA from 89 children with NS from 89 families was screened for mutations in 40 NS genes by targeted sequencing of custom amplicons (TSCA)...