Radial contractility of actomyosin rings facilitates axonal trafficking and structural stability
Abstract
Most mammalian neurons have a narrow axon, which constrains the passage of large cargoes such as autophagosomes that can be larger than the axon diameter. Radial axonal expansion must therefore occur to ensure efficient axonal trafficking. In this study, we reveal that the speed of various large cargoes undergoing axonal transport is significantly slower than that of small ones and that the transit of diverse-sized cargoes causes an acute,...
Paper Details
Title
Radial contractility of actomyosin rings facilitates axonal trafficking and structural stability
Published Date
Mar 17, 2020
Journal
Volume
219
Issue
5
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