Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement
Abstract
DNA methylation plays an important role in both normal human development and risk of disease. The most utilized method of assessing DNA methylation uses BeadChips, generating an epigenome-wide "snapshot" of >450,000 observations (probe measurements) per assay. However, the reliability of each of these measurements is not equal, and little consideration is paid to consequences for research. We correlated repeat measurements of the same DNA...
Paper Details
Title
Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement
Published Date
May 1, 2020
Journal
Volume
1
Issue
2
Pages
100014 - 100014
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