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New antidepressant utilization pre- and post-bereavement: a population-based study of partners and adult children.

Published on Mar 17, 2020in Social Psychiatry and Psychiatric Epidemiology3.152
· DOI :10.1007/S00127-020-01857-1
Katherine Ornstein18
Estimated H-index: 18
(ISMMS: Icahn School of Medicine at Mount Sinai),
Melissa D. Aldridge9
Estimated H-index: 9
(ISMMS: Icahn School of Medicine at Mount Sinai)
+ 4 AuthorsLau Caspar Thygesen22
Estimated H-index: 22
(University of Southern Denmark)
Abstract
Bereavement is associated with increased morbidity and mortality, but few studies have examined the specific timing of depression onset. This study examines the risk of developing new-onset depression in adult children and partners by month, 1 year before and after death. Using population-based registers in Denmark, we assembled a cohort of 236,000 individuals who died a natural death (2010–2016). Partners and adult children of the deceased were identified and demographic and prescription data were collected. GEE logistic regression was used to model whether the bereaved received a new antidepressant prescription around the death of their loved one across 24 time intervals (12 months before and after death). Male and female partners had an increase in receipt of new antidepressant prescriptions in the 11 months after the death of their partner, with a peak increase 2 or 3 months after death. Partners also increased new antidepressant prescription use 2 months before death. Characteristics of the decedents including cause of death were not associated with new antidepressant prescription in the surviving partner. Adult children did not have increased odds of being prescribed new antidepressants at any time. Both male and female partners have increase in new antidepressant utilization before and after the death of their partner. Our work points to the importance of supporting partners not only after the death of their partner, but also in the period before death when families may be actively engaged in caregiving for the seriously ill.
  • References (43)
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References43
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#1Ivan Urits (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 5
#2Jacquelin PeckH-Index: 2
Last. Omar Viswanath (Creighton University)H-Index: 3
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Purpose of Review While clinicians have been using antidepressants for off-label indications in the treatment of chronic pain in recent years, newer studies have proven effectiveness and provided additional mechanistic understanding and defined potential adverse effects. As depression and chronic pain are frequently comorbid conditions, the use of antidepressants has allowed for treatment of both conditions concomitantly in the same patient population.
1 CitationsSource
#1Katherine Ornstein (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 18
#2Jennifer L. Wolff (Johns Hopkins University)H-Index: 33
Last. Amy S. Kelley (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 20
view all 5 authors...
Caregiving in the last years of life is associated with increased depression and negative health outcomes for surviving spouses, many of whom are themselves in poor health. Yet it is unclear how of...
Source
#1Christina Blanner Kristiansen (University of Southern Denmark)H-Index: 2
#2Jesper Nørgaard Kjær (Aarhus University Hospital)H-Index: 3
Last. A. Matthew Prina ('KCL': King's College London)H-Index: 18
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Purpose To conduct a systematic review and meta-analysis examining the association of the prevalence of depression and time since spousal loss in widowed people.
2 CitationsSource
#1Judith B. Vick (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 5
#2Katherine Ornstein (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 18
Last. Jennifer L. Wolff (Johns Hopkins University)H-Index: 33
view all 5 authors...
Abstract Context Family caregivers play critical and demanding roles in the care of persons with dementia through the end of life. Objectives The objective of this study was to determine whether caregiving strain increases for dementia caregivers as older adults approach the end of life, and secondarily, whether this association differs for nondementia caregivers. Methods Participants included a nationally representative sample of community-living older adults receiving help with self-care or in...
4 CitationsSource
#1Ingrid Egerod (UCPH: University of Copenhagen)H-Index: 27
#2Gudrun Kaldan (Copenhagen University Hospital)H-Index: 3
Last. Dorthe Overgaard (UCPH: University of Copenhagen)H-Index: 11
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ABSTRACT Introduction Fibrotic interstitial lung disease (f-ILD) comprises a group of diseases with lung scarring and reduced life expectancy. The short time from diagnosis to death affects the patients’ bereaved spouses, who risk developing prolonged grief. In Denmark palliative care is most often offered to cancer patients. Aim We aimed to investigate the experience of spouses of f-ILD patients during the final stages of illness and up to the first year after the patient’s death to investigate...
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AIM: To examine antidepressant prescribing trends in New Zealand adults from 2008-2015. METHODS: Antidepressant prescribing data was sourced via the Ministry of Health. Data were examined by year, type of drug, ethnicity, gender, age and location of district health board. RESULTS: All individuals dispensed an antidepressant in New Zealand were included. In 2015, 12.6% of all New Zealanders were prescribed an antidepressant (16% of females and 9% of males) an increase of 21% from 2008. The larges...
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#2Ulrika Kreicbergs (KI: Karolinska Institutet)H-Index: 22
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This study aimed to validate the Swedish version of the Prolonged Grief Disorder-13 tool (PG-13) by examining its psychometric properties, including factor structure, discriminant and concurrent va ...
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#1Anders Prior (AU: Aarhus University)H-Index: 6
#2Morten Fenger-Grøn (AU: Aarhus University)H-Index: 16
Last. Mogens Vestergaard (AU: Aarhus University)H-Index: 38
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#1Katherine Ornstein (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 18
#2Amy S. Kelley (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 20
Last. Jennifer L. Wolff (Johns Hopkins University)H-Index: 33
view all 4 authors...
To date, knowledge of the experiences of older adults’ caregivers at the end of life has come from studies that were limited to specific diseases and so-called primary caregivers and that relied on the recollections of people in convenience samples. Using nationally representative, prospective data for 2011, we found that 900,000 community-dwelling Medicare beneficiaries ages sixty-five and older who died within the following twelve months received support from 2.3 million caregivers. Nearly nin...
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#1Mai-Britt Guldin (AU: Aarhus University)H-Index: 9
#2Maiken Ina Siegismund Kjaersgaard (AU: Aarhus University)H-Index: 8
Last. Mogens VestergaardH-Index: 38
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The loss of a close relative is a common event, yet it is associated with increased risk of serious mental health conditions. No large-scale study has explored up to now the importance of the bereaved person's relation to the deceased while accounting for gender and age. We performed a nationwide Danish cohort study using register information from 1995 through 2013 on four sub-cohorts including all persons aged ≥18 years exposed to the loss of a child, spouse, sibling or parent. We identified 1,...
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