Metabolic phospholipid labeling of intact bacteria enables a fluorescence assay that detects compromised outer membranes
Abstract
Gram-negative bacteria possess an asymmetric outer membrane (OM) composed primarily of lipopolysaccharides (LPSs) on the outer leaflet and phospholipids (PLs) on the inner leaflet. The loss of this asymmetry due to mutations in the LPS biosynthesis or transport pathways causes the externalization of PLs to the outer leaflet of the OM and leads to OM permeability defects. Here, we used metabolic labeling to detect a compromised OM in intact...
Paper Details
Title
Metabolic phospholipid labeling of intact bacteria enables a fluorescence assay that detects compromised outer membranes
Published Date
Jun 1, 2020
Journal
Volume
61
Issue
6
Pages
870 - 883
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