Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses
Abstract
Although similar in molecular composition, synapses can exhibit strikingly distinct functional transmitter release and plasticity characteristics. To determine whether ultrastructural differences co-define this functional heterogeneity, we combine hippocampal organotypic slice cultures, high-pressure freezing, freeze substitution, and 3D-electron tomography to compare two functionally distinct synapses: hippocampal Schaffer collateral and mossy...
Paper Details
Title
Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses
Published Date
Mar 1, 2020
Journal
Volume
30
Issue
11
Pages
3632 - 3643.e8
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