Obesity, Hypertension, and Cardiac Dysfunction
Abstract
Obesity and hypertension, which often coexist, are major risk factors for heart failure and are characterized by chronic, low-grade inflammation, which promotes adverse cardiac remodeling. While macrophages play a key role in cardiac remodeling, dysregulation of macrophage polarization between the proinflammatory M1 and anti-inflammatory M2 phenotypes promotes excessive inflammation and cardiac injury. Metabolic shifting between glycolysis and...
Paper Details
Title
Obesity, Hypertension, and Cardiac Dysfunction
Published Date
Mar 13, 2020
Journal
Volume
126
Issue
6
Pages
789 - 806
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Notes
History