Explaining the link between adiposity and colorectal cancer risk in men and postmenopausal women in the UK Biobank: A sequential causal mediation analysis.

Published on Mar 17, 2020in International Journal of Cancer4.982
· DOI :10.1002/IJC.32980
S. Ghazaleh Dashti4
Estimated H-index: 4
(IARC: International Agency for Research on Cancer),
Vivian Viallon4
Estimated H-index: 4
(IARC: International Agency for Research on Cancer)
+ 5 AuthorsNeil Murphy27
Estimated H-index: 27
(IARC: International Agency for Research on Cancer)
Mechanisms underlying adiposity-colorectal cancer (CRC) association are incompletely understood. Using UK Biobank data, we investigated the role of C-reactive protein (CRP), hemoglobin-A1c (HbA1c), and (jointly) sex hormone-binding globulin (SHBG) and testosterone, in explaining this association. Total effect of obesity vs normal-weight (based on waist circumference, body mass index, waist-hip ratio) on CRC risk was decomposed into natural direct (NDE) and indirect (NIE) effects using sequential mediation analysis. After a median follow-up of 7.1 years, 2070 incident CRC cases (men = 1,280; postmenopausal women = 790) were recorded. For men, the adjusted risk ratio (RR) for waist circumference (>/=102 vs /=88 vs
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